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Description: Sildenafil Citrate is a drug that comes in various trade names. Learn about the trade names and the uses of this especially prescribed to men drug. Sildenafil Citrate for Impotence - Know What Else the Drug Cures. Men always pride of their virility and when they lose sex drive, they feel too berserk for their incapacity. But since 1998, men began to have hope for their erectile dysfunction. Thanks to the scientists of Pfizer for their discovery of sildenafil citrate. People may not know about this generic name but it is more popular in its trade name - Viagra. Pfizer competitors have tadalafil and vardenafil that treat the same male problem.

Buy Viagra in Best drug store


This drug is a phosphodiesterase type-5 inhibitor. It is also a vasodilator for hypertension. It does not only treat erection problems in male but also pulmonary hypertension. Pfizer trade names are Viagra and Revatio, drugs for erectile dysfunction and pulmonary arterial hypertension, respectively. How does the Best drug store work?
- Viagra - As a treatment for impotence, sildenafil's action is for improvement of the flow of blood into the penis. Used with the aid of sexual stimulation, erection can follow and be maintained for sexual satisfaction.
- Revatio - The drug relaxes, dilates and widens the muscle cells in the blood vessel walls to allow flow of the blood to the lungs. This reduces the blood pressure and strain on the lungs as well as the heart.

Taking the drug for erectile dysfunction


Only males with erectile dysfunction should take Viagra or any drug similar to it. Furthermore, before taking the medicine you have to consult first your doctor otherwise, you cannot buy this prescribed drug. Your doctor is the best authority to tell you how to implement the medication. After being prescribed, here is how it is often taken. First, you should follow the instruction of your doctor as to how to take it. But to reiterate and outline the ways, the drug for this problem is taken an hour before having sex. It can be taken before and after meal but when you have it before a large meal, it may take time to manifest effect. Sildenafil citrate is only taken one time in a day - do not go over this. To get the best effect from the drug and also for sexual enjoyment, prior foreplay between you and your sexual partner is a must-do thing. Unless you are fully aroused, this drug will have no effect. As you take this, think or pretend that you are not under the influence of Viagra. There are a number of ''don'ts'' when you take sildenafil.
- Do not eat grapefruit or drink the juice when using this drug as some chemicals in the fruit can cause side effects.
- No alcohol should be ingested.
- Discontinue the use when you feel it is too strong for you.
- When sildenafil does not produce the desired effect, do not take additional tablet; you are supposed to have it once a day only. Instead discuss the problem with your doctor.
- Do not take this drug when you are under treatment for impotence using other medication.

Impotence and side effects of Viagra


Just like other medicines, sildenafil can cause side effects - not necessarily appearing on all users. Individual reactions are varied and at different level. Among the common noted side effects include headache, indigestion, blocked nose, flushed face, dizziness, blurry vision and prolonged or painful erection. Experiencing the adverse effects of sildenafil citrate, the first thing to do is stop the usage. Then pay an immediate visit to your general practitioner or doctor. Do not push your medication to its limit. Your doctor will have other ways to treat your sexual problem.
Manufactured by pharmacological companies under the name of Sidenafil, commonly known as Viagra, is a popular drug being utilized to treat erectile dysfunction as well as pulmonary arterial hypertension. The main mechanism of action of this drug is that inhibits the cGMP-specific phosphodiesterase type 5, an enzyme that promotes the depolarization of cGMP. This nerve signaling pathway is responsible for the regulating of blood flow and muscle activity.
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Viagra increases the blood flow as well as relaxes the muscle and increases the exercise capacity of patients suffering from pulmonary arterial disease. It has also been successfully utilized by mountain climbers to combat high altitude pulmonary edema due to altitude sickness. It was initially a breakthrough product of one of the leading pharmacological companies of the world, Pfizer. As sidenafil already contains nitrate it is important to consult your doctor before taking sidenafil with any other drug containing nitrates like nitroglyscine. Nitrates are usually taken to control blood pressures and are an important component of anti angina medications. But if they are combined with Viagra they may cause serious and unwanted side effects like a sudden drop in blood pressure. Another adverse effect that has been noted in some patients especially those with a history of cardiac diseases is the sudden loss of vision. Vision complains usually consists of cynopsia (vision that is tinted blue), impaired vision, blurry vision and photophobia. Duodenal ulcers and headaches are also complaints of the general masses after taking Viagra.

Care should be exercised by patients who are taking protease inhibitors like the patients of HIV. Protease inhibitors inhibit the metabolism of sidenafil thereby increasing their plasma half life and in return enhancing their adverse effects. Also patients with a history of cardiac diseases, retinopathies, hepatic dysfunctions, stroke, renal malfunctions or hypotension are contraindicated to the usage of Viagra as it may cause the side effects of the drug to worsen. The mode of acting of the drug is to protect the GMP by the PDE5. As the nitric oxide binds to the gaunylate cyclase receptor resulting in increasing levels of cGMP and in return vasodilatation. Sidenafil is metabolized in the liver through the CYP 450 enzyme system mainly through a main pathway of CYP3A4 and another minor route of CYP2C9. The time taken to reach its maximum concentration in the plasma is about 1 hour. After metabolized into its several metabolites that still have 20% of the sidenafil activity, they are actively eliminated from the body mainly by the feces and also by the urine.

Viagra is popular among our culture and is widely used by many people out there. Apart from their clinical uses, Sidenafil is also utilized commercially and recreationally by athletes to increase their muscle size and enhance their blood supply, they have also been used in cut flowers to keep them standing straight for up to a week longer than their natural life span rather than wilting down. Sidenafil is also used at times with opiates and other drugs to warrant the side effects of it.